503 Tofacitinib for recalcitrant cutaneous dermatomyositis

Treatment of recalcitrant dermatomyositis with efalizumab.

Sir, Dermatomyositis (DM) is an auto-immune disease that primarily affects muscles and skin. Muscle weakness appears in the shoulders and hips in particular. Skin symptoms include a diffuse violaceous erythema and oedema, predominantly of the upper face including the orbita, and violaceous-red papules of the finger (Gottron papules). The pathogenesis of DM is unclear, but recent studies suggest...

Deep Cutaneous Ulcers in Dermatomyositis

A 28-year-old woman was referred to our hospital with treatment-resistant dermatomyositis (DM). She had been receiving moderate-dose prednisolone for 6 months; however, her myalgia, weakness, and cutaneous rash persisted. She had a rash on her face, chest, shoulders, elbows, knees, and her periungual areas, as well as a heliotrope rash and Gottron’s sign. There were deep ulcers over the bilater...

Intravenous immunoglobulin for recalcitrant subacute cutaneous lupus erythematosus.

Sir, Subacute cutaneous lupus erythematosus (SCLE), first described by Sontheimer et al. (1) in 1979, represents a distinct subtype of lupus erythematosus (LE) with specific clinical and serological features. Characteristically, skin lesions appear in a non-scarring papulosquamous, annular, polycyclic or psoriasiform pattern primarily located in the sun-exposed areas such as the upper back and ...

Cutaneous amyloidosis associated with amyopathic dermatomyositis.

Pneumomediastinum in dermatomyositis: association with cutaneous vasculopathy.

OBJECTIVES To study the pathogenesis of pneumomediastinum in polymyositis/dermatomyositis (PM/DM). PATIENTS AND METHODS The clinical records of 48 patients with PM/DM were reviewed, focusing mainly on the presence of pneumomediastinum and cutaneous vasculopathy, and the chest radiographic changes. A patient with pneumomediastinum with a characteristic change in his bronchus is described in de...